PROCESS FOR PREPARING BISMORANOLIN DERIVATIVES

摘要

Moranoline derivs. I [X=C6H4O(CH2)nOC6H4; n=2,3 were prepd. Thus, a mixt. contg. 18g p-hydroxybenzaldehyde, 10g 1,3-dibromopropane, 21g K2CO3, and 100mL DMF was heated for 4.5 hrs. with 6g moranoline in DMSO to give I [X=C6H4O(CH2)3OC6H4 . At 1mg/kg orally in rats, I [X=C6H4O(CH2)3OC6H4 gave an 87% inhibition of a blood sugar-level increase from 2g of sucrose/kg.