| 摘要 |
A normally solid, hydrophilic compound capable of binding with Tc-99m to form a cationic complex is provided. The compound has a formula selected from: <IMAGE> (A) or <IMAGE> (B) wherein: R, R', R'', R1, R2, R3, R4, R5 and R6 are each independently selected from hydrogen; or substituted or unsubstituted alkyl, alkylene, aryl, alkylaryl, arylalkyl, monocycloalkyl, polycycloalkyl, heterocyclic and carbocyclic groups; and R plus Ri in formula (A) may be taken together to form a cyclic compound; A, A', A'', A1, A2, A3, A4, A5 and A6 are independently neutral functional elements, each having a free electron pair available for accepting a proton to provide a charged ligand and having the capability of complexing with Tc-99m to form a cationic complex; Y1, Y2, Y3, Y4, Y5 and Y6 are each independently selected from hydrogen; or substituted or unsubstituted alkyl, alkylene, aryl, alkylaryl, arylalkyl, monocycloalkyl, polycycloalkyl, heterocyclic and carbocyclin groups; Z is an anion; i is an integer from 0 to 6; j, j' and j'' are each independently 0 or 1; k1, k2, k3, k4, k5 and k6 are each independently 0 or 1; n, n' and n'' are each independently the integer 1 or 2; n1, n2, n3, n4, n5, n6, are independently 0 or 1; and n7 and n8 are each an integer from 1 to 6; and n9 and n10 are each an integer from 1 to 3. These compounds are capable of reducing technetium to form stable cationic complexes. Radiolabelled such complexes are useful in connection with radiodiagnostic test of myocardial and/or hepatobiliary tissues.
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