发明名称 |
FOERFARANDE FOER FRAMSTAELLNING AV ANTIGENISKA IMMUNOGENISKA SUBUNITS AV HSV-1 OCH HSV-2 |
摘要 |
<p>Herpes virus subunit antigens suitable for vaccine use are prepared by (1) treating virus-infected cells with a surfactant and varying concentrations of salt to extract and solubilize viral-directed glycoproteins, (2) fractionating the solubilized material by chromatographic procedures to enrich the viral-directed glycoproteins and to remove unwanted proteins and nucleic acids, and (3) optionally treating the subunit antigens with deoxyribonuclease and formaldehyde to assure safety.</p> |
申请公布号 |
FI66020(B) |
申请公布日期 |
1984.04.30 |
申请号 |
FI19780002769 |
申请日期 |
1978.09.11 |
申请人 |
MERCK & CO INC |
发明人 |
LARSON VIVIAN;LEHMAN ERNEST DALE |
分类号 |
C12N7/00;A61K39/245;(IPC1-7):C12N7/04 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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