POLYMERIC AGENT FOR RELEASING 5-AMINOSALICYLIC ACID OR ITS DERIVATIVES INTO THE GASTROINTESTINAL TRACT, PHARMACEUTICAL FORMULATION COMPRISING SAID AGENT,METHOD OF ITS PREPARATION AND METHOD OF PREPARING SAID FORMULATION

摘要

An intestinal anti-inflammatory preparation comprising a polymeric agent for releasing 5-aminosalicylic acid or its salts is disclosed. The polymeric agent comprises a nonabsorbable pharmacologically acceptable organic polymer backbone containing aromatic rings to which are covalently bonded via azo bonds a plurality of salicylic acid or salicylate salt groups. The azo bonds attach to the salicylates' 5-position carbon. The polymer's azo bonds undergo bacterial cleavage in the mammalian lower bowel to release 5-aminosalicylic acid and/or its salts.