| 摘要 |
This invention relates to novel 23-demycinosyltylosin-derivatives possessing potent and broad spectrum anti-bacterial activity, processes for their preparation and pharmaceutical compositions containing them. …<??>The compounds are of the general formula …<CHEM>… wherein… R1 is hydrogen or acyl;… R2 is acyl;… R3 is hydrogen or acyl; or R2 and R3 are together a carbonyl group linking the 3 sec -and 4 sec -hydroxyl groups;… R4 is hydrogen or acyl;… R6 is methyl, hydroxymethyl, fluoromethyl, chloromethyl, bromomethyl, iodomethyl, di-(C1-C6)alkylaminomethyl, acyloxymethyl, CHO or a group of the formula CH=R5 wherein… R5 is as hereinbelow defined; and… Z is an iminogroup R5 or,… when… R6 is fluoromethyl, chloromethyl, bromomethyl, iodomethyl, acyloxymethyl, CHO, di(C1-C6)alkylaminomethyl,… Z can also be oxo;… and the pharmaceutically acceptable salts thereof. |
