LEUKOTRIENE B4 ANALOGOUS COMPOUND, ITS PREPARATION, AND REMEDY CONTAINING IT AS ACTIVE INGREDIENT

摘要

NEW MATERIAL:A compound shown by the formula I [R<1> is H, or 1-4C alkyl; R<2> is 1-8C alkylene; R<3> is H, 1-15C alkyl, or CH2-A-R<4> (A is cis-vinylene, or acetylene; R<4> is 1-12C alkyl); double bond between C10-C11 shows E]. EXAMPLE:( 5RS )-6,7-Dihydro-5, 8-methano- 13,14,15,16,17,18,19,20 -octanol-leukotriene B4. USE:An antiphlogistic and an antiallergic. Having an antagonism on leukotriene B4. PROCESS:An aldehyde compound shown by the formula II (R<1a> is 1-4C alkyl) is reacted with an allenylboric acid or allenylborate shown by the formula III(R<5> is H, or 1-4C alkyl) in an inert organic solvent at -78 deg.C- room temperature, and, if necessary, saponified, to give a compound shown by the formula I .