Process for the manufacture of sodium cefoperazone.

摘要

Crystalline sodium cefoperazone and a process for its manufacture in a form essentially free of residual organic solvents which comprises the steps of combining an aqueous acetone solution containing from about 3 to 30 percent (w/v) of sodium cefoperazone with about a four-fold volume (v/v) of a solution of acetone-methylene chloride (95:5, v/v) at a temperature of about 5-40°C.; and separating and drying the resulting crystalline sodium cefoperazone.