| 摘要 |
<p>NEW MATERIAL:The peptide of formula I (A is Ser or Tyr; B is Gly or Glu; X is Ala or Val; the steric configuration of amino acid residues is D, L or DL). EXAMPLE:H-Ser-Gln-Glu-Asp-Pro-Asn-Ala-Tyr-Ser-Gly-Glu-Leu-Phe-Asp-Ala-OH. USE:A synthetic intermediate of the peptide of formula II[Y is OH or NR<1>R<2> (R<1> and R<2> are H or alkyl)] having analgesic activity. Useful for the preparation of an antiserum acting specifically to the peptide of formula II, and for the detection and determination of prodynorphin. PROCESS:After protecting the amino groups and carboxyl groups having no participation in the reaction, the required peptide chains are bonded successively to the C-terminal according to the peptide synthesis process. The protecting groups are removed from the obtained ptotected peptide by conventional method to obtain the objective peptide of formula I .</p> |
