摘要 |
<p>PURPOSE:To prepare mycophenolic acid in high yield, by cultivating a fungus belonging to the genus Penicillium. CONSTITUTION:A variant such as Penicillium brevicompactum AJ117112 (FERM- P 6619) belonging to the genus Penicillium, having methionine demanding properties, capable of producing mycophenolic acid is inoculated into a methionine- containing medium, cultivated under aerobic conditions at 20-35 deg.C for 100- 500hr, and mycophenolic acid is collected from the culture solution.</p> |