发明名称 |
FREMGANGSMAATE VED FREMSTILLING AV DYNORFINDERIVATER |
摘要 |
Novel compounds are provided which differ in their effect from dynorphin(1-13) by neither potentiating nor antagonizing narcotics, such as morphine, in naive animals. In tolerant hosts the new compounds potentiate narcotic or peptide induced analgesia, and in addition are less susceptible to degradation than dynorphin(1-13). …<??>The compounds are amidated dynorphin(1-10) to (1-12), in which one or more amino acids, particularly AA<8> and AA<9>, may be exchanged with different amino acids. …<??>Particularly preferred of the new compounds are polypeptides having ten amino acids with nitrogen containing moieties at both termini. |
申请公布号 |
NO832107(A) |
申请公布日期 |
1983.12.12 |
申请号 |
NO19830002107 |
申请日期 |
1983.06.09 |
申请人 |
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE, |
发明人 |
LEE, NANCY M.,;CHANG, JAW-KANG,;LOH, HORACE H., |
分类号 |
C07K14/655;A61K38/00;A61K38/22;A61P25/04;C07K7/06;C07K14/575;C07K14/665 |
主分类号 |
C07K14/655 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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