| 摘要 |
<p>P.C. 5935A N-(Tetrazol-5-yl) Prostaglandin Carboxamides Three classes of N-(tetrazol-5-yl) prostaglandin carboxamides having the bottom side chain substitutions of C-16 phenyl or substituted phenyl (Class 1), C-16 phenoxy or substituted phenoxy tClass 2) and C-15 n-pentyl, 2-hexyl or 2-methyl-2-hexyl (Class 3) have been synthesied using the corresponding acyk imidazole intermediates and 5-amino tetrazole. The three classes of prostaglandins have different and selective biological activities which are antiulcer (Class 1), fertility control (Class 2) and bronchodilator or fertility control (Class 3).</p> |
