| 摘要 |
PURPOSE:To obtain the titled fine particles useful as an immunological assay reagent, by reducing the surfaces of polymeric fine particles e.g. acrylonitrile, binding the resultant functional groups directly or to other functional groups and then to an immunologically active substance. CONSTITUTION:The surfaces of polymeric fine particles, e.g. acrylonitrile or methacrylonitrile, are reduced, and the reactivity of the resultant functional groups is used and directly or bound to other functional groups and then to an immunologically active substance, e.g. a luetic treponema antigen, hepatitis B surface antigen or rubella antigen, to give the aimed fine particles containing the immobilized immunological active substance. A crosslinking monomer having at least two carbon-carbon double bonds in the molecule in an amount of 30mol% or less based on the total monomer may be added to crosslink the polymer. Divinylbenzene, divinyltoluene, etc. may be cited as the crosslinking agent. |
