FURYL-NONATETRAENE DERIVATIVES AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESSES FOR THEIR PREPARATION, STARTING COMPOUNDS USED IN THESE PROCESSES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The new furyl-nonatetraene derivatives of the formula …… and the pharmaceutically acceptable salts thereof, e.g. (E,E,E,E,) -3,7-dimethyl-9-(2,4,5-trimethyl-3-furyl)- 2,4,6,8-nonatetraenoic acid ethyl ester, are effective in regressing the growth of tumors and chondrosarcoma and they are useful as medicaments for therapy of acne, psoriasis and other dermatological disorders. They may be therefore included in pharmaceutical preparations. …The compounds of the formula I may be prepared by a process which comprises… a) reacting a compound of the formula… B-C(CH3) = CH-CH = CH-C(CH3) = CH-COOR<1><0> II… with a new compound of the formula …… or… b) reacting a new compound of the formula …… with a compound of the formula… HO(CH2)nN(R<7>R<8>) V… or… HN(R7R<8>) VI… The meaning of the substituents see inside the description.