| 摘要 |
<p>NEW MATERIAL:The compound of formulaI(R<1> is H, 1-10C lower alkyl, or tri(1-7C hydrocarbon)-silyl group; R<2> is 1-10C alkyl or 5-6-membered cycloalkyl; R<3> and R<4> are H or OH-protecting group; R<5> is H or methyl; A is carbonyl or hydroxymethylene; B is group of formula CH2-CH2, CH=CH, or C C) and its salt. EXAMPLE:dl-7,8-Dehydro-PGE1 (THP compound) methyl ester. USE:Antiulcer agent. It has various prostaglandin-like activities, and is useful also as the synthetic intermediate of prostaglandin. PROCESS:The compound of formulaIcan be prepared by reacting the 7-hydroxy- PG of formula II (R<31> and R<41> are OH-protecting group) with methanesulfonyl chloride in the presence of a base, and if necessary, subjecting the product to the elimination of the protective group, hydrolysis, or reduction of the 9-position carbonyl group.</p> |
