10-BROMOSANDWICINE, 10-BROMOISOSANDWICINE, METHODS FOR PREPARING AND USING SAME AND PHARMACEUTICAL COMPOSITIONS THEREOF

摘要

10-bromosandwicine and 10-bromoisosandwicine and acid addition salts thereof are disclosed. These novel compounds are valuable intermediates for the preparation of 10-brominated Nb-quaternary sandwicine derivatives which exhibit heart rhythm regulatory and adrenolytic properties. The novel compounds themselves also possess similar pharmacological properties. 10-bromosandwicine is prepared by brominating sandwicine and can subsequently be isomerized into 10-bromoiso-sandwicine.