| 发明名称 |
ANALOGIFORFARANDE FOR FRAMSTELLNING AV N?722-SUBSTITUERADE L-ARGININDERIVAT |
| 摘要 |
N<2>-Substituted L-arginine esters of the formula I in which the symbols have the meaning stated in the claim are highly specific thrombin inhibitors. They are suitable for the treatment or prophylaxis of thrombophilic diatheses. The compounds of the formula I are prepared by a) reacting compounds of the formula II with alcohols R-H in the presence of an acid catalyst, or b) reacting a compound of the formula II with an alcohol R-H and with a thionyl halide and, where appropriate, converting the resulting compound into a salt with an acid. <IMAGE> |
| 申请公布号 |
SE428014(B) |
申请公布日期 |
1983.05.30 |
| 申请号 |
SE19760008791 |
申请日期 |
1976.08.25 |
| 申请人 |
MITSUBISHI CHEMICAL INDUSTRIES LTD;SHOSUKE OKAMOTO |
发明人 |
1) S * OKAMOTO;2) R * KIKUMOTO;3) Y * TAMAO;4) K * OHKUBO;5) T * TEZUKA;6) S * TONOMURA;7) A * HIJIKATA |
| 分类号 |
A61K38/00;C07D211/04;C07D211/16;C07D211/46;C07D295/185;C07D307/91;C07D311/82;C07D321/10;C07D405/12;(IPC1-7):07D211/16;07C143/78 |
主分类号 |
A61K38/00 |
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