| 摘要 |
<p>Chemiluminescent-labeled conjugates of the formula: Chemi-R-L wherein Chemi represents a moiety which is capable of undergoing a change in chemical structure with the production of light, R is a linking group, and L is a specifically bindable ligand, such as an antigenic protein or polypeptide, a hapten or an antibody, or a binding analog thereof. The chemiluminescent moiety may be luminol, isoluminol, pyrogallol or luciferin. Preferred labeled conjugates are of the formula: wherein one of R1 and R2 is hydrogen and the other is -NR3R4; R3 is hydrogen or straight chain alkyl containing 1-4 carbon atoms and R4 is wherein ? = 1-3 and L(CO? is the ligand or analog bound through an amide bond. Intermediates produces in the synthesis of such preferred conjugates are also disclosed.</p> |
