| 摘要 |
<p>PURPOSE:2-Guanidino-4-[2-(N-protected formamide)ethylthiomethyl]thiazole is treated with an appropriate deprotecting agent to produce the titled compound used as a remedy for gastric ulcer in high yield. CONSTITUTION:The reaction of guanylthiourea with a compound of formula I(A is reactive group; R is protecting group) gives 2-guanidino-4-[2-(N-protected formamide)ethylthiomethyl]thiazole of formula II and the product is treated with a deprotecting agent such as trifluoroacetic acid, 85% sulfuric acid or 90% phosphoric acid to give 2-guanidino-4-[2-(fromamide)ethylthiomethyl]thiazole of formula III. USE:A drug showing an antagonistic action on himstamine H2.</p> |
