摘要 |
Novel pyrimidine derivatives of the formula; <IMAGE> ps wherein Ar is phenyl or naphthyl, which may be substituted by lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, halogen, nitro, trifluoromethyl or di-lower alkylamino; R1 is lower alkyl, lower cycloalkyl, trifluoromethyl, lower alkoxycarbonyl, phenyl or benzyl, and the phenyl may be substituted by halogen; R2 is hydrogen or lower alkyl; R3, R4 and R5 are hydrogen,lower alkyl, lower alkenyl or lower alkoxy, or R3 and R4 or R4 and R5 combine with each other to represent trimethylene, tetramethylene or butadienylene, or salts of them, are excellent antimicrobial agents. |