PROCESS FOR PRODUCING VACCINES AND COMPOSITION THEREOF APPLICABLE THROUGH THE RESPIRATORY ORGANIS

摘要

A vaccine for animals subject to Bordetella bronchiseptica infection comprises an aqueous suspension of viable cells of a modified Bordetella bronchiseptica strain. This strain is not merely attenuated and avirulent but has been modified so that it will colonize the respiratory mucosa of animals for only a limited time before it is cleared, causing no adverse effect on the animals. During the limited period of growth on the respiratory mucosa, however, the strain is capable of inducing local resistance to B. bronchiseptica infection. Swine are thereby protected against atrophic rhinitis and turbinate atrophy and dogs against tracheobronchitis (kennel cough). A vaccine dose form comprises a first vial containing freeze-dried cells of the modified B. bronchiseptica and a second vial contains sterile water preferably with a wetting agent.