PROCESS FOR THE MANUFACTURE OF NOVEL ANTIGENS

摘要

New antigen derivatives are disclosed which comprise an antigen and at least one muramyl-peptide covalently bonded thereto, if appropriate by a bridge member. The derivatives may be represented by the formula: A - ¢Z0-1 - MP !n in which A is the radical of an antigen, Z is a bridge member, MP is a muramyl-peptide radical and n is a positive integer. The novel derivatives provide a marked potentiation of the immuno-response to the antigen, in particular a cell-mediated immunity under clinically acceptable conditions of administration.