发明名称 TRYPSIN INHIBITOR OBTAINED FROM FINE ALGAE
摘要 PURPOSE:To provide a new compound obtained from a fine alga and useful for pancreatitis therapeutic medicines, anti-inflammatory medicines, clinical examination medicines, medicines for diseases accompanied by circulatory failures and organ function failures, etc. CONSTITUTION:The compound of the formula, mol.wt.: 986; amino acid ratio: Lys:val:Glu:Thr:Leu:N-Metyr=1.02:0.99:0.97:1.01:1:0.98. The compound is obtained e.g. as follows: culturing a blue green alga, Miclocystis aeruginosa, in a MA medium with aeration, obtaining a lyophilized product from the culture solution, extracting the lyophilized product with 80% methanol, vacuum-concentrating the extraction product, and subsequently subjecting the residue to a chromatography such as ion exchange chromatography or reverse phase column chromatography.
申请公布号 JPH05331189(A) 申请公布日期 1993.12.14
申请号 JP19920163860 申请日期 1992.05.29
申请人 ITO HAM KK 发明人 YAMAGUCHI KATSUMI;MURAKAMI MASAHIRO
分类号 A61K8/00;A61K8/49;A61K38/55;A61K49/00;A61P1/00;A61P9/00;A61P29/00;A61Q19/10;C07K1/20;C07K5/10;C07K7/06;C07K14/81;C12N9/99;C12P21/02;C12R1/89 主分类号 A61K8/00
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