发明名称 |
Preparation of 13-oxabicyclo[10.3.0]pentadecane |
摘要 |
This invention relates to the preparation of 13-oxabicyclo[10.3.0]pentadecane. More specifically, this invention relates to a process for preparing 13-oxabicyclo[10.3.0]pentadecane which comprises the steps of: (a) reacting cyclododecanone with elemental bromine in an organic solvent to form alpha -bromocyclododecanone; (b) reacting alpha -bromocyclododecanone with malonic acid dialkyl ester and alkali metal alcoholate to form the ketodiester 2-(2-oxocyclododec-1-yl)-malonic acid dialkyl ester; (c) hydrolyzing and decarboxylating the ketodiester from step (b) to from the corresponding 2-oxocyclododec-1-yl-acetic acid in an aqueous alkaline solution; (d) purifying the product of step (c) by extraction with an organic solvent and obtaining 2-oxocyclododec-1-yl-acetic acid; (e) reacting the product of step (d) with a lower alcohol to form a corresponding ester; (f) reducing the product of step (e) with a complex metallic hydride to form 2-(2-hydroxyethyl)-cyclododecanol; and (g) heating the product of step (f) in the presence of an acid catalyst to form 13-oxabicyclo[10.3.0]pentadecane.
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申请公布号 |
US4360468(A) |
申请公布日期 |
1982.11.23 |
申请号 |
US19810306771 |
申请日期 |
1981.09.29 |
申请人 |
HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN |
发明人 |
UPADEK, HORST;BRUNS, KLAUS |
分类号 |
C07D307/93;(IPC1-7):C07D307/93 |
主分类号 |
C07D307/93 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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