ANTISECRETORY THIADIAZOLE DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The invention relates to a thiadiazole derivative of the formula I: I in which Y is O, S, CH2, SO or a direct bond; m is 0 to 4 and n is 1 to 4 provided that when Y is S, O or SO m is 1 to 4, and when Y is O or SO n is 2 to 4; R1 is H or (C1-10)alkyl; A is 3,4-dioxocyclobuten-1,2-diyl or C=Z in which Z is O, S, NCN, NNO2, CHNO2, NCONH2, C(CN)2, NCOR2, NCO2R2, NSO2R2 or NR3 in which R2 is (C1-6)alkyl or (C6-12)aryl and R3 is H or C1-6)alkyl; B is (C1-6)alkoxy, (C1-6)alkylthio or NR4R5 in which R4 and R5 are independently H, (C1-10)alkyl, C3-6(alkenyl), (C3-6)alkynyl, (C2-6)(primary hydroxy)alkyl, (C2-6)(primary amino)alkyl or C3-6)cycloalkyl or R4 and R5 are joined to form a 5- or 6- membered saturated ring optionally containing an additional O or NH: and the salts thereof.