| 摘要 |
<p>Imidazo and pyrimido-pyridoindole derivatives of the general formula: in which n is 1 or O, Rl is a hydrogen or halogen atom, or an alkyl, alkoxy or trifluoromathyl radical, R2 is an alkyl, cycloalkyl, cycloalkyl-alkyl, phenyl or benzyl radical, the phenyl and benzyl raclicals being unsubstituted or substituted by a halogen atom or an alkyl or alkoxy radical, R3 is a hydrogen atom or an alkyl radical and R4 is a hydrogen atom or an alkyl radical, the alkyl and alkoxy radicals having from 1 to 4 carbon atoms and their pharmaceutically acceptable acid addition salts, except compounds in which simultaneously n = 1, Rl, R3 and R4 are hydrogen atoms and R2 is a methyl radical, are useful in treating convulsions. They are prepared by reacting a compound of the general formula: (II) wherein R5 is ethyl or mcthyl with an amine R2NH2, to form an amide wherein -OR5 is replaced by -NHR2 and cyclising thc amide in aqueous formaldehyde.</p> |
