发明名称 |
PYRIMIDONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL DERIVATIVES CONTAINING THEM |
摘要 |
Compounds (1) …<CHEM>… in which… R<1> and R<2> are C1-C4 alkyl or together with the nitrogen atom to which they are attached form a pyrrolidino or piperidino group;… Y is methylene or sulphur;… X is methylene or oxygen provided that X is methylene when Y is sulphur;… Z is hydrogen or C1-C4 alkyl; and… R<5> is hydrogen, C1-4 alkyl or -A-B where… A is C1-C4 alkylene and… B is optionally substituted heteroaryl or phenyl are histamine H2-antagonists. Processes for their preparation and pharmaceutical compositions containing them are also described. |
申请公布号 |
EP0049173(A3) |
申请公布日期 |
1982.06.30 |
申请号 |
EP19810304540 |
申请日期 |
1981.10.01 |
申请人 |
SMITH KLINE & FRENCH LABORATORIES LIMITED |
发明人 |
COOPER, DAVID GWYN;SACH, GEORGE SIDNEY |
分类号 |
C07D401/12;A61K31/505;A61P43/00;C07D213/38;C07D401/14;C07D405/14;C07D409/14;C07D417/14;C08B30/12;C13K1/06 |
主分类号 |
C07D401/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|