| 摘要 |
PURPOSE:To readily and economically obtain a compound useful as a medicine having action such as improvement of cerebral metabolism, increase of cerebral blood stream, vasodepression, sedation, etc., in high purity and yield, by hydrogenating 4-azide-3-hydroxylactic acid. CONSTITUTION:4-Azide-3-hydroxylactic acid expressed by the formula derived from an optically active epichlorohydrin is reacted in the presence of metallic catalyst (e.g. palladium, platinum) in a solvent such as methanol, etc., under room temperature of 20-25 deg.C at ordinary pressure for 3-15hr to provide the aimed product. Palladium-carbon powder having about 10% palladium content is especially excellent from view point of yield and economics as the catalyst and is used in an amount of 0.5-50wt.% based on the raw material expressed by the formula. |
