INDANYL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

摘要

The invention provides a compound of the general formula (I). wherein Ar represents a phenyl or pyridyl radical each unsubstituted or substituted by one or more substituents selected from halogen, (C1-C4)alkyl. and trifluoromethyl, X represents oxygen or sulphur, R1 represents (C1-C4)alkyl unsubstituted or substituted by one or more substituents selected from fluorine and chlorine, A represents -CH2-CH2-CH2-, -CH=CH-CH2-, , , or , wherein Y represents oxo, hydroxyimino, (C1-C4)alkoxyimino, phenylhydrazono or p-toluenesulphonylhydrazono, Z represents hydroxy, (C1-C6)acyloxy, R1SO3-, amino,(C1-C6)acylamino, R1SO2HN- or cyano, n represents 0, 1 or 2, and R2 represents (C1-C4)alkyl, or phenyl unsubstituted or substituted by one or more substituents selected from halogen, (C1-C4)alkyl, nitro and carboxy, the -CY- or -CHZ- group or -CH2- group of -CH=CH-CH2-being either meta or para to ArX, and V represents hydrogen, (C1-C6)acyl or R1SO2-, and salts thereof, and a process for their preparation. These compounds have pharmaceutical activity, e.g. anti-inflammatory activity.