发明名称 |
6(R)-(2-(8'-ETHERIFIED-HYDROXY-2',6'-DIMETHYLPOLYHYDRO-NAPHTHYL-1')-ETHYL)-4(R)-HYDROXY-3,4,5,6-TETRAHYDRO-2H-PYRAN-2-ONES, THE HYDROXY ACID FORM OF SAID PYRANONES, THE SALTS AND ESTERS OF SAID ACID FORM, PROCESS FOR PREPARING THE SAME AND AN ANTIHYPERCHOLESTEROLEMIC PHARMACEUTICAL COMPOSITION CONTAINING THE SAME |
摘要 |
<p>6(R)-[2-(8'-Etherified-hydroxy-2',6'-dimethylpolyhydronaphthyl-1')-eth yl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones are prepared from the corresponding 8'-acyloxy compounds, some of which are naturally occurring, by protection of the 4(R)-hydroxyl and the 2-keto group, followed by reductive removal of the 8'-acyloxy group, etherification of the resulting 8'-hydroxyl and removal of the protecting groups. The products inhibit the biosynthesis of cholesterol.</p> |
申请公布号 |
EP0033536(A3) |
申请公布日期 |
1982.02.24 |
申请号 |
EP19810100727 |
申请日期 |
1981.02.02 |
申请人 |
MERCK & CO. INC. |
发明人 |
SMITH, ROBERT L.;LEE, TA-JYH |
分类号 |
C07C59/62;C07D309/30;C07F7/18;(IPC1-7):07D309/30;61K31/365;07C59/11 |
主分类号 |
C07C59/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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