Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel

摘要

The invention relates to novel substituted indoles of general formula (I) in which Ra to Rd are defined as in claim 1. The tautomers, stereoisomers, mixtures and salts of Ra to Rd have valuable properties. The compounds of general formula (I) in which Rb or Rd contains a cyanophenyl group form valuable intermediate products in order to produce the remaining compounds of general formula (I), and the compounds of general formula (I) in which Rb or Rd contain a R1NH-C(=NH)-phenyl group in addition to the tautomers and stereoisomers thereof have valuable pharmacological properties, especially a thrombin inhibiting effect which extends the thrombin time and a fibrinogen receptor antagonistic effect.