Total synthesis of the utero-evacuant substance d,l-zoapatanol

摘要

A method for the synthesis of racemic 2S* 3R*-6E-(2''-hydroxyethylidene)-2-methyl-2-(4',8'-dimethyl-5'-oxo-7'-no nenyl)-oxepan-3-ol is described. The naturally occurring product, 2S,3R-6E-(2''-hydroxyethylidene)-2-methyl-2-(4',8'-dimethyl-5'-oxo-7'- nonenyl)-oxepan-3-ol, is one of the active components of the zoapatle plant.