摘要 |
9 alpha ,21-Dihalo-11 beta ,17 alpha -dihydroxy-6 alpha -fluoro-16 alpha -methylpregna-1,4-diene -3,20-dione 17-esters of the formula <IMAGE> in which X is bromine or chlorine, and Ac is an acyl group derived from a carboxylic acid, are distinguished by a high local antiinflammatory activity with a diminished systemic effect, for which reason they can be used in medicine to alleviate and control inflammatory states. They are obtained by conventional addition of hypochlorous acid onto a corresponding 9(11)-unsaturated starting material. |