| 摘要 |
NEW MATERIAL:A piperazine compound shown by the formula I (X is H, halogen, alkoxy, carboxy, alkoxycarbonyl, or R<3>CO-; R<3> is 1-4C alkyl; R<1> is H or alkyl; R<2> is H or alkyl) and its inorganic or organic acid addition salt. EXAMPLE:1-Phenyl-4-methylcarbamoylpiperazine USE:Having immunologically adjusting action or antarthritic action, useful as an immunological activator. Useful for diseases, e.g., rheumatoid arthritis, autoimmune diseases, e.g., multiple myositis, etc., various infections diseases, various cancers, etc., low toxic, extremely useful as a drug. PROCESS:For example, a 1-aryl-4-chlorocarbonylpiperazine shown by the formula II is condensed with an amine shown by the formula III in a solvent, e.g., methylene chloride, etc. at 0-120 deg.C, to give a compound shown by the formula I. |
