| 摘要 |
The invention provides a pharmaceutical composition for topical application comprising an essentially saturated solution of hydrocortisone in aqueous propylene glycol solution containing at least 15% but less than 50% by weight of propylene glycol, the proportion of hydrocortisone in the total composition being at least 0.08% but not greater than 0.4% by weight of aqueous propylene glycol and from 0.025 to 0.4% based on the total weight of the composition, the said composition being characterized by a pH in the range of 2.7 to 3.3, and the substantial absence of metallic cations. Such compositions have excellent storage stability and surprisingly high effectiveness of the hydrocortisone contained therein.
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