| 摘要 |
Compounds of formula I <IMAGE> (I) wherein either R1 and R2 are both hydrogen or R1 and R2, taken together, represent a group of formula (a): <IMAGE> (a) in which R5 is hydrogen, halogen or C1-4 alkyl, R3 is hydrogen or a group of formula (b): <IMAGE> (b) in which R6 is hydrogen or C1-4 alkyl, and R4 is hydrogen or a group of formula -CHR7COOH, where R7 is hydrogen or C1-4 alkyl, provided that: (i) when R3 is a group of formula (b), then R1, R2 and R4 are all hydrogen, (ii) when R3 is hydrogen, then R4 is -CHR7COOH, and (iii) when R1 and R2, together, represent a group of formula (a), then R3 is hydrogen; possess pharmacological activity, in particular anti-inflammatory activity and are particularly useful in treatment of rheumatoid arthritis.
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