| 摘要 |
<p>Aq. protein solns. contain a surfactant (I) with a linear structure consisting of alternate weakly hydrophobic and weakly hydrophilic regions. Pref. (I) is a homopolymer, copolymer or block copolymer of formula (Ia) R2Y-(X)n-R3 (Ia) ((X)n is a chain of n members of formula -CHR1CHR1O- or -CHR1O- in any order; n is 2-80, pref. 8-45; Y is O or NH; R1 is H, Me or Et, but must be Me or Et in at least half the gps. X; R2 and R3 are H or organic gps.). The solns., esp. insulin solns., are stabilised against denaturation of the protein, which can affect its immunological and biological properties. (I) prevents the adsorption of the protein on surfaces and hence prevents sec. reactions such as aggregation. The solns. may be used for therapeutic purposes (e.g. as insulin solns. with depot action), or for treating hydrophobic surfaces to prevent their adsorbing and denaturing effect on proteins, e.g. during the prepn. and purificn. of proteins, esp. by chromatography or ultrafiltration.</p> |
