| 摘要 |
PURPOSE:To prepare the titled substance having antitumor acitvity and low toxicity, and useful as a remedy for tumor, etc., and having beta-1,3-glucopyranose units in the main chain and the side chains, by oxidizing the product of beta-1,3-glucan-producing bacteria with periodic acid, etc., and reducing the oxidation product. CONSTITUTION:beta-1,3-Glucan obtained by culturing the strain of Pestalotia No.815 (FERM-P No.5147), etc., is oxidized with periodic acid or its water-soluble salt at a low temperature below 15 deg.C for about 2-10 days. The oxidation product is separated from the reaction mixture, mixed with an aqueous medium, and reduced with a reducing agent such as sodium borohydride, etc., to obtain the objective polysaccharide composed of a main chain having beta-1,3-glucopyranose units of formula I (Glc is glucopyranose residue) as recurring units, and side chains of formula II (n is 0-1) and/or formula III (R is group of formula IV). |
