| 发明名称 |
Microbiological modification of antibiotic A23187 esters |
| 摘要 |
Cultivation of Streptomyces chartreusis NRRL 11407 in the presence of antibiotic A23187 methyl ester produces 16-hydroxy A23187 methyl ester, 16-hydroxy-N-demethyl A23187 methyl ester, and N-demethyl A23187 methyl ester. Hydrolysis of the products affords the corresponding free acids which form dimeric complexes with divalent cations.
|
| 申请公布号 |
US4247703(A) |
申请公布日期 |
1981.01.27 |
| 申请号 |
US19780971616 |
申请日期 |
1978.12.20 |
| 申请人 |
ELI LILLY AND COMPANY |
发明人 |
ABBOTT, BERNARD J.;FUKUDA, DAVID S. |
| 分类号 |
C07D493/10;(IPC1-7):C07D493/10 |
主分类号 |
C07D493/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
