| 摘要 |
<p>Osmotically driven active agents dispenser for use in a watercontaining environment that pumps a solution of active agent, such as a drug, at a predetermined, constant rate. The dispenser is in the form of a coated tablet comprising; a core of an osmotically effective active agent composition; and an inexpandable wall that encloses the core, has a controlled permeability to water and has inherent properties, such as brittieness, or sites of structural weakness, that are responsive to the pressure generated within the dispenser by imbibtion of water from the environment by the core through the wall to form at least one, and usually many, passageway in situ in the wall through which the active agent composition in solution is pumped water is being imbibed into the dispenser.</p> |
