| 摘要 |
A process for the preparation of the sodium salt of the antibiotic (6R,7R)-3-carbamoyloxymethyl-7-[Z-2-(fur-2-yl)-2-methoxyiminoacetamido ]-ceph-3-em-4-carboxylic acid (cefuroxime) which comprises subjecting a corresponding 3-N-protected carbamoyloxymethyl compound to alcoholysis in a substantially anhydrous medium using a basic catalyst comprising the sodium salt of an acid having a pKa value of not less than 3.5 whereby sodium cefuroxime or a solvate thereof can be obtained directly without isolation of the corresponding acid. Sodium cefuroxime tetrahydrofuran solvate is also provided as a new entity. |
