Octahydro pyrazolo (3,4-g)quinolines, process for their preparation and pharmaceutical compositions containing them.

摘要

Octahydropyrazolo [3,4-g] quinolines of the general formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="28" wi="79" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein
<UnorderedLists id="ula01" listStyle="none"><ListItem>R is (C<Sub>1-3</Sub>)alkyl or allyl;</ListItem><ListItem>R<Sup>1</Sup> is H or CH<Sub>2</Sub>X wherein X is OCH<Sub>3</Sub>, SCH<Sub>3</Sub>, CN, SO<Sub>2</Sub>CH<Sub>3</Sub> or CONH<Sub>2</Sub>; and</ListItem><ListItem>pharmaceutically-acceptable acid addition salts thereof.</ListItem></UnorderedLists>

These compounds, dopamine agonists, useful in treatment of Parkinsonism and in inhibiting secretion of prolactin, are prepared by reacting a corresponding 7-dimethylaminomethylene-6-oxo-derivative with hydrazine hydrate.