| 摘要 |
<p>2-Chlorosulfinyl azetidin-4-one (I; R = remaining group of carboxylic acid; R1 = protecting group of carboxylic acid) were prepd. by reaction of penicillin sulphoxide ester (II) with N-chloro-halogenating agent in inert org. inert solvent at 75-175≰C. The improvement comprises carrying ont reaction in presence of organic solvent insol, weakly basic crosslinked poly 4-(vinylphridine) polymer in wt. ratio of polymer to II of 1:1-1:5. The polymer is crosslinked to 1-10% with e.g. divinyl benzene, N,N'-methylene-bisacrylamide, trimethacrylate or divinylsulphon.</p> |
