PROCEDEU PENTRU PREPARAREA UNOR DERIVATI AI LEUROSINEI

摘要

Leurosine derivatives of the formula (I), (I) wherein R is hydrogen or formyl, or pharmaceutically acceptable acid addition salts thereof were prepared by oxidizing leurosine or an acid addition salt thereof, optionally formylating the thus-obtained product and then separating, and, if desired, converting any of the free bases into its acid addition salt. The new compounds of the invention possess strong cytostatic activity, and can be used in the human therapy with great advantage.