| 摘要 |
<p>The compounds for use as oral hypoglycemic agents are of the formulae:
<CHEM>
<CHEM>
<CHEM>
<CHEM>
<CHEM>
or
<CHEM>
wherein X is hydrogen, fluorine, chlorine, bromine, nitro, cyano, lower alkyl or lower alkoxy, X being other than hydrogen in formula (I);
Y and Y min are each amino, lower N-monoalkylamino, lower N,N-dialkylamino, pyridylamino, pyrrolidino, piperidino, homopiperidino, morpholino, thiomorpholino, 2,3-dihydroisoindolyl and 1,2,3,4-tetrahydroisoquinolyl; and
Z is oxygen or sulfur. Several methods for the preparation of these compounds are described; e.g. alpha , alpha min -dibromo-o-xylene by reaction with piperidine gives 1,1 min -[1,2-phenylene-bis-(methylene)]bispiperidine.
<??>Novel compounds claimed are: those of formula (I) wherein X is other than hydrogen or methyl, or wherein Y is pyridylamino and Y min is other than pyridylamino; and the compounds of formulae (IV) and (VI). Compositions claimed comprise an effective blood sugar lowering amount of a compound of formulae (I) to (VI) and a carrier material. </p> |
