GLYCOPEPTIDE ANTIBIOTIC COMPLEX FROM STREPTOALLOTEICHUS

摘要

A novel water-soluble basic glycopeptide antibiotic complex designated herein as Bu-2231 is produced by ferimentation of a Bu-2231-producing strainn of Streptoalloteichus hindustanus. Complex Bu-2231 and two of its major components designated herein as Bu-2231 A and B are found to inhibit the growth of various Cram-posltlve and Gram-negativc and acid-fast bacteria as well as certain plant pathogens. The complex and components Bu-2231 A and B are also0 useful in inhibiting the growth of various tumors in rodents, for example, Walker ?56 carcinosarcoma and Lewis Lung carcinoma.