| 摘要 |
PURPOSE:To obtain a 4-carbon substituted azetidinone useful as a raw material for antibiotics, by reacting a 2-azetidinone derivative having a lower acyloxy group or halogen at the 4-position with an organomagnesium or organocopper compound. CONSTITUTION:A 2-azetidinone derivative of formula I: (R<1> is group which will not take part in the reaction; R<2> is lower acyloxy, (un)substituted alkylsulfonyl, arylsulfonyl, phenoxy group, or halogen) is reacted with a nucleophilic organomagnesium compound of formula II: (R<3> is lower alkyl, allyl, (un)substituted ethynyl, (un)substituted aryl group, etc.) or an organocopper compound of formula III: (R<4> is lower alkyl or aryl group) to give an azetidinone derivative of formula IV. |
