A composition for controlling dental caries where an enzyme (alpha-glucosidase) that degrades bacterial components is attached to an anchor molecule to prolong the degradative effects

摘要

A composition for controlling bacterial growth/colonisation is provided. The composition comprises an enzyme, an anchor molecule coupled to the enzyme to form an enzyme-anchor complex, with the anchor being capable of attaching to a substrate proximal to a bacterial colony. The attachment to the substrate permits prolonged retention time of the enzyme-anchor complex where the bacterial colony is present to increase the effectiveness of the complex. The polysaccharide degrading enzymes are derivatised or coupled to the anchor molecules so that they are able to absorb to surfaces and structures in the oral cavity, and inhibit the proliferative bacterial colonisation associated with the plague matrix.