| 摘要 |
(A) Cpds. of the fllowing formulae labelled with the radio-isotopes 32P or 33P are stated to be new: and the labelled cpds. 1,2-dicarboxyethylene-1-phosphonic acid and ethylene-1,1-diphosphonic acid. (R=H or CH2OH; n=3-10; R1=H, 1-20C alkyl, 2-20C alkenyl, aryl, phenylethyl, benzyl, halo, OH, opt. substd. amino, carboxymethyl, CH2PO3H2, CHOH.PO3H2 or - [CH2C(PO3H2)2]n'H; n' = 1-15; R2 = H, alkyl, NH2, benzyl, halo, OH, CH2COOH, CH2PO3H2 or CH2CH2PO3H2; m=3-9; R3=H or alkyl; p=2-4; X and Y = H or OH). Salts of these cpds. are included. (B) Claims are restricted to compsns. for treatment of tumours contg. these cpds. The cpds. may be used in the treatment of calcareous tumours, such as primary- and metastic bone tumours and tumours which calcify soft tissue. They may also be used in combined therapy with other chemotherapeutic agents. The cpds. have a high selectivity for calcareous tumours of up to 40:1 with respect to normal bone. They have very low soft-tissue retention and few side-effects. |
