| 摘要 |
1, 3, 4-Trisubstituted-4-aryl piperidines (I; R1=C1-8 alkyl, C3-8 alkynyl, C3-8 alkynyl, C4-8 (cycloalkyl) alkyl, R2= hydrogen, C1-4 alkyl, C2-6 alkenyl, R3= C1-4 alkyl, C2-6 alkenyl, R4=hydrogen, hydroxy, C1-3 alkoxy, C1-12 alkanoyloxy), useful as antagonists against hypnotics, were prepd. Thus, compd. II(R1/1=C1-8 alkyl, C4-8 (cycloalkyl) alkyl or benzyl, R2,R3, R4 are given) was reduced (when R1/1 is benzyl, II is dibenzylated. realkylated, when R1/1 is methyl, II is methylated and realkylated) to give I.
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