发明名称 |
TRICHOTHECIN EPOXIDE BASE COMPOUND HAVING NEW ANTIILEUKOSIS ACTION |
摘要 |
There are provided novel anti-leukemic epoxides which are isolated from Baccharis megapotamica. The novel compounds are characterized by a 12,13-epoxytrichothecene central ring system which is spanned by a dienic macrolide ester side chain. The active compounds are characterized by the presence of an oxygen atom in the A-ring which takes the form of either a beta hydroxy group in the 8 position together with an unsaturated bond at the 9: 10 position or, alternatively, an epoxide group lying between the 9 and 10 position. Compounds devoid of either of these groups show no anti-leukemic activity. |
申请公布号 |
JPS54103898(A) |
申请公布日期 |
1979.08.15 |
申请号 |
JP19780130096 |
申请日期 |
1978.10.24 |
申请人 |
RESEARCH CORP |
发明人 |
BURUUSU BII JIYAABUISU;RICHIYAADO JII DEIRII JIYUNIA;ESU MOORISU KUPUCHIYAN |
分类号 |
C07D493/10;A61K31/35;A61K31/365;A61P35/02;C07D493/20;C07D493/22 |
主分类号 |
C07D493/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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